{"id":9039,"date":"2014-09-23T04:00:42","date_gmt":"2014-09-23T09:00:42","guid":{"rendered":"http:\/\/www.paristn.net\/articles\/?p=9039"},"modified":"2014-09-22T19:30:46","modified_gmt":"2014-09-23T00:30:46","slug":"american-heart-association-reports-inflammation-may-be-key-to-diabetesheart-disease-link","status":"publish","type":"post","link":"https:\/\/www.paristn.net\/articles\/2014\/09\/23\/american-heart-association-reports-inflammation-may-be-key-to-diabetesheart-disease-link\/","title":{"rendered":"American Heart Association reports Inflammation may be key to Diabetes\/Heart Disease link"},"content":{"rendered":"

\"AmericanSan Francisco, CA<\/strong> – Inflammation may be the reason high blood sugar levels damage blood vessels, raising the possibility that anti-inflammatory medications might someday be used to lower the risk of blood vessel disease in people with diabetes, according to a study presented at the American Heart Association\u2019s High Blood Pressure Research Scientific Sessions 2014.<\/p>\n

\"Heart<\/a>

Heart illustration with artery close up. (American Heart Association)<\/p><\/div>\n

\u201cThese findings may explain why good blood sugar control is not sufficient to avoid the development of diabetes-induced cardiovascular diseases,\u201d said Carlos F. S\u00e1nchez-Ferrer, M.D., Ph.D., study author and professor of pharmacology at the Universidad Aut\u00f3noma de Madrid, Spain. \u201cWe need to find new medications focused on reducing inflammation.\u201d<\/p>\n

Using cultured smooth muscle cells from the main human artery (aorta), researchers found:<\/h4>\n
    \n
  • In the absence of inflammation, excess glucose in the culture fluid didn\u2019t enter the cells.<\/li>\n
  • When extra glucose was forced into the cells, no harm was done in the absence of inflammation.<\/li>\n
  • When the inflammation-stimulating protein interleukin-1 (IL-1) was introduced, more glucose entered the cells.<\/li>\n
  • With IL-1, the glucose entering the cells was metabolized via chemical pathways that spur escalating inflammation, overwhelming the cells\u2019 ability to counteract it.<\/li>\n
  • In the presence of the anti-inflammatory drug anakinra, which blocks the activity of IL-1, the deleterious changes didn\u2019t occur.<\/li>\n<\/ul>\n

    \u201cWe need to reduce the inflammatory environment associated with diabetes,\u201d S\u00e1nchez-Ferrer said. \u201cChanges in life-style, such as physical exercise and weight reduction, are important not only because they reduce blood sugar but because they reduce inflammation.\u201d<\/p>\n

    The researchers plan to test whether the effect is similar in cultured cells from the lining of blood vessels and explore the blood sugar\/inflammation connection in animals.<\/p>\n

    Co-authors are Concepci\u00f3n Peir\u00f3, Ph.D.; Tania Romacho, Ph.D.; Ver\u00f3nica Azcutia, Ph.D.; Laura Villalobos, Ph.D.; Enrique Fern\u00e1ndez, Ph.D.; Juan P. Bola\u00f1os, Ph.D.; and Salvador Moncada, M.D., Ph.D.<\/p>\n

    The Spanish Plan Nacional de I+D, Junta de Castilla y Le\u00f3n, Sociedad Espa\u00f1ola de Farmacologia-Almirall; and Fundaci\u00f3n Eugenio Rodriguez Pascual funded the study.<\/p>\n","protected":false},"excerpt":{"rendered":"

    San Francisco, CA – Inflammation may be the reason high blood sugar levels damage blood vessels, raising the possibility that anti-inflammatory medications might someday be used to lower the risk of blood vessel disease in people with diabetes, according to a study presented at the American Heart Association\u2019s High Blood Pressure Research Scientific Sessions 2014.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[86],"tags":[2538,2554,216,2994,3508,4763],"class_list":["post-9039","post","type-post","status-publish","format-standard","hentry","category-health","tag-american-heart-association","tag-cardiovascular-disease","tag-diabetes","tag-glucose","tag-high-blood-sugar","tag-san-francisco-ca"],"_links":{"self":[{"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/posts\/9039","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/comments?post=9039"}],"version-history":[{"count":1,"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/posts\/9039\/revisions"}],"predecessor-version":[{"id":9040,"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/posts\/9039\/revisions\/9040"}],"wp:attachment":[{"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/media?parent=9039"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/categories?post=9039"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/tags?post=9039"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}