![\"American](\"http:\/\/www.clarksvilleonline.com\/wp-content\/uploads\/2010\/12\/American-Heart-Association-new-logo-480x230.jpg\" "\\"American"){kind=logo}
Dallas, TX<\/strong> – Genetically inherited high levels of cholesterol<\/a> are twice as common in the United States as previously believed, affecting 1 in 250 adults, according to new research in the American Heart Association\u2019s journal Circulation.<\/em><\/p>\nThe condition, familial hypercholesterolemia (FH), leads to severely elevated cholesterol levels from birth and is a leading cause of early heart attack.<\/p>\n
![\"Prepping](\"http:\/\/www.clarksvilleonline.com\/wp-content\/uploads\/2016\/03\/cholesterol-test-480x320.jpg\" "\\"Prepping")
<\/a>Prepping the patient to draw blood for a cholesterol test. (American Heart Association)<\/p><\/div>\n
\u201cIt\u2019s more common than we thought and it\u2019s important to look for it at a young age because someone with FH may have no symptoms until there is serious heart disease. A common story<\/a> might be someone who develops chest pain or has a heart attack in their 30s or 40s \u2013 even though they look healthy, eat well, and are thin and fit,\u201d said Sarah de Ferranti, M.D., M.P.H., lead author of the study, assistant professor of pediatric cardiology at Harvard Medical School, and director of preventive cardiology at Boston Children\u2019s Hospital in Massachusetts.<\/p>\n Based on studies conducted outside of the United States in selected and less racially and ethnically diverse populations, prior to this research it was thought that FH affected about 1 in 500 adults. The current study used data from 36,949 adults who took part in the 1999-2012 National Health and Nutrition Examination Survey (NHANES) and extrapolated to the 210 million U.S. adults aged 20 years and older.<\/p>\n Researchers used high levels of low-density-lipoprotein cholesterol (considered \u201cbad\u201d because it contributes to plaque buildup in arteries) and early heart disease in a person or close relative to determine probable\/definite cases of FH.<\/p>\n Among the findings:<\/strong><\/p>\n The clinical picture of FH varies by age and weight. For example, this NHANES analysis suggests that FH becomes more common with increasing age (affecting 1 in 1,557 people in their 20s, but 1 in 118 people in their 60s) and with obesity (affecting 1 in 172 obese people, but 1 in 325 non-obese people).<\/p>\n \u201cThe fact that FH varies by age and obesity shows that there are other factors at play in raising LDL-cholesterol levels in addition to genetics,\u201d de Ferranti said, who noted a lack of genetic information in NHANES as a limitation to the study.<\/p>\n \u201cThe next step forward could be to take blood samples from a data set such as NHANES and look for the prevalence of FH genetic mutations and the heart attack rate,\u201d she said.<\/p>\n [320left]If diagnosed at a young age, treatments such as statin medications can be started to reduce LDL levels and the risk of heart disease. Control of other risk factors, such as smoking, high blood pressure, as well as lack of exercise, poor diet and increased body weight, are particularly important for people with FH.<\/p>\n \u201cIf you\u2019re born with FH you have lifelong exposure to high cholesterol, making your heart attack risk similar to someone decades older,\u201d de Ferranti said. \u201cIf you know that somebody has had an early heart attack in your family, consider asking for everyone to be checked.\u201d<\/p>\n A scientific statement<\/a> by the American Heart Association, published December 1, 2015 in Circulation<\/em>, states FH is \u201cunderdiagnosed and undertreated worldwide,\u201d and proposed an ambitious research agenda to help meet the unique challenges FH poses for patients, families, and healthcare providers.<\/p>\n Co-authors are Angie Mae Rodday, Ph.D., M.S.; Michael M. Mendelson, M.D., S.M.; John B. Wong, M.D.; Laurel K. Leslie, M.D., M.P.H. and R. Christopher Sheldrick, Ph.D. Author disclosures are on the manuscript.<\/p>\n The Patient-Centered Outcomes Research Institute and the Tommy Kaplan Fund funded the study.<\/p>\n Additional Resources<\/strong><\/p>\n American Heart Association Rapid Access Journal Report Dallas, TX – Genetically inherited high levels of cholesterol are twice as common in the United States as previously believed, affecting 1 in 250 adults, according to new research in the American Heart Association\u2019s journal Circulation. The condition, familial hypercholesterolemia (FH), leads to severely elevated cholesterol levels from […]<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[86],"tags":[2538,8201,88,6774,4030,6775,2542,2966,10817,2557,1836,369,2038],"class_list":["post-11072","post","type-post","status-publish","format-standard","hentry","category-health","tag-american-heart-association","tag-boston-childrens-hospital","tag-cholesterol","tag-circulation","tag-dallas-tx","tag-harvard-medical-school","tag-heart-attack","tag-high-cholesterol","tag-hypercholesterolemia","tag-lipoprotein","tag-massachusetts","tag-obesity","tag-united-states"],"_links":{"self":[{"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/posts\/11072","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/comments?post=11072"}],"version-history":[{"count":1,"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/posts\/11072\/revisions"}],"predecessor-version":[{"id":11073,"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/posts\/11072\/revisions\/11073"}],"wp:attachment":[{"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/media?parent=11072"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/categories?post=11072"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.paristn.net\/articles\/wp-json\/wp\/v2\/tags?post=11072"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n
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